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With the surge of diet pills that contain hoodia gordonii, it would be best to know exactly how this miracle drug reacts and takes action inside the body. Based on current researches done on the properties of hoodia gordonii and its effect on the human body, they have pinpointed a certain chemical that is primarily responsible for the anorexiant effect brought by the plant. They say that this substance called P57 works primarily in the brain that functions similar to glucose. P57 is a substance that brings signals to the brain telling that the body is full already when the person has actually not eaten anything. In the process, this prompts the brain not to feel hunger. Therefore, the person will not feel the desire to eat which contributes to weight loss. This significant finding is the basis why hoodia gordonii is used for weight loss as an appetite suppressant.